Adenosine-Containing Molecules Amplify Glucose Signaling and Enhance Txnip Expression
نویسندگان
چکیده
منابع مشابه
Tandem ChoRE and CCAAT Motifs and Associated Factors Regulate Txnip Expression in Response to Glucose or Adenosine-Containing Molecules
BACKGROUND Thioredoxin interacting protein (Txnip) is a multifunctional protein involved in regulation of cell cycle events and cellular metabolism. The expression of Txnip is known to be induced by glucose, adenosine-containing molecules, and other physiological cues; however, the underlying regulatory mechanisms remain elusive. METHODOLOGY/PRINCIPAL FINDINGS In this study, using promoter re...
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Thioredoxin-interacting protein (Txnip) acts as a negative regulator of thioredoxin function and is a critical modulator of several diseases including, but not limited to, diabetes, ischemia-reperfusion cardiac injury, and carcinogenesis. Therefore, Txnip has become an attractive therapeutic target to alleviate disease pathologies. Although Txnip has been implicated with numerous cellular proce...
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ژورنال
عنوان ژورنال: Molecular Endocrinology
سال: 2009
ISSN: 0888-8809,1944-9917
DOI: 10.1210/me.2008-0383